An illustration by Patrick Campbell from the book Why We Suck by Denis Leary

Illustration: Patrick Campbell

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Throughout Why We Suck, Denis highlights the differences between men and women. In one graphic (see above), he diagrams the male brain and the female brain. "We had to change some of the words of the graphic," Oprah jokes. "'Breasts' instead of you know what—the other word."

"And 'oral sex' instead of you know what," Gayle jokes.

"What I was trying to accomplish here is the complicated level of the female brain versus the simplicity of the male brain," Denis says. "But let me point out—this guy? This is actually a complicated guy. Because most guys it would just be sex and sandwiches."