Angelika and Jake

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In September 2007, Oprah met Angelika and Jake, young adults who said they were born in the wrong body. These transgender youths began transitioning to their new genders at a young age.

Oprah also met Dr. Marci Bowers, a biological man who became a woman late in life. Even after transitioning to the opposite sex, Dr. Bowers remains married to her wife of more than 20 years.

At the end of the show, Oprah still had unanswered questions. "This was a conversation that could have gone on for hours," she says. "We're picking up where we left off talking to men, fathers and husbands who, after many years of marriage, decided to live as women."

Having a transgender spouse may be a deal breaker for some wives...but not as many as you may think. About 25,000 women responded to an poll that asked, "Would you stay with your husband if he told you he wanted to live as a woman?" More than 10 percent of you said you would stay married.