Oprah reads Zachary's letter.

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Wives aren't the only ones affected by this life-changing decision. Many men who become women are also fathers. Oprah says she was inspired to meet the families of these men after receiving a letter from Zachary, the 13-year-old son of Jenny Boylan. Jenny was known as Jim before her sex-change operation.

In the letter, Zachary writes, "Sometimes it's true that I wish I had a regular father, but only because I don't really remember what it was like to have a normal family. Sometimes it's hard to have a family that is different, but most of the time, I think I'm the luckiest kid on earth. I know people from lots of different kinds of families, but no matter how different they are, they really are all just people. My goal is that someday everybody will be treated with love."

"That's my goal, too," Oprah says.