Katherine Heigl

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Even though success seems to have come quickly, Katherine says she's been trying to climb her way to the top since childhood. "I'd done a small television show," she says. "I'd done lots of movies and TV movies and Hallmark movies, whatever to pay the bills."

Since her big break on Grey's Anatomy, Katherine says her life was suddenly filled with many rewarding roles and life events. "I dreamed about these moments, and I think I hoped I would have them, but you don't know. So when the lucky break hits, it's like being Cinderella and hopefully midnight doesn't come."

Although many people would consider Katherine to be lucky, Oprah thinks Katherine should give herself more credit. "I think luck is the moment of preparation, all the years of preparation, meeting the moment of opportunity," Oprah says. Katherine agrees and thinks the word "grace" is a better word to describe her success. "I think that I've worked hard. I've tried to grow not only as a person but as an actor," she says. "I've tried to prepare myself to be in the right place and the right time."