Katherine Heigl

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She's been Knocked Up, has worn 27 Dresses and won an Emmy for her stand-out role as Izzie Stevens on Grey's Anatomy. Katherine Hiegl is being called the new "it" girl—a title she is a little hesitant about. "I'm scared of that," she says. "I don't know what that means. Does that mean tomorrow there's another 'it' girl?"

Although Katherine hopes she's here to stay, being at the forefront of Hollywood's radar has its benefits. "Now that success has come, the opportunities are there, which is so huge," Katherine says. "I mean, there are these roles that they want me to play that I would have had to beat my head against a wall to get only a year ago or two years ago."

In the hit romantic comedy 27 Dresses, Katherine plays Jane, a woman who's always the bridesmaid, never the bride. In reality, Katherine says she has worn far fewer taffeta dresses than her character. "I've only had to do it twice, thank God," Katherine says. "I did it just recently for my sister who got married in October, and it's a job. It's an intense job to make sure that this person has the best day of their life, that none of the problems fall on their shoulders."