Julia Roberts

10 of 15
6. Julia Roberts
With her megawatt smile and infectious laugh, it's no wonder why award-winning actress Julia Roberts has been on the Oprah Show 21 times. Since Julia's first appearance in 1989, she's become a wife, a mother of three and a dear friend of Oprah's.

Oprah and Julia have made a lot of great memories over the years, like Julia's best friend's makeover and Julia's first interview with Tom Hanks!

Fun fact: Did you know Oprah and Julia were in a movie together? Find out which one!