Bob Greene says he once thought Oprah suffering from depression.

7 of 15
Bob has confronted Oprah about other issues. One day while taking a walk through her front yard, Bob told Oprah he thought she was suffering from low-grade depression.

Oprah remembers the moment very clearly. "I said, 'What? Me? Depressed? I can't be depressed. I know what depression is. I'm not depressed,'" she says. "He said, 'I don't know. Something's off. Your movements are slower. Your responses are slower. There's a dullness about you. If I were you, I'd look into what that is. I think there's something going on.'"

When Bob looked into Oprah's eyes, he says she wasn't really there. "She was somewhere else. She was very vacant and distracted, and it was alarming to me," he says. "I think I felt she was losing her zest for life, and that was one of the saddest moments."

Though Oprah doesn't think she was depressed, she does know she was exhausted. "I let the well run dry. That's what happened when I started to get unbalanced, when I started to not take time for myself, when I started to go unconscious."

If you don't feel fulfilled and you're not taking of care of yourself, Bob says food becomes much more attractive. "It's a way to comfort yourself in hard times," he says.