Then, in 1991, Rosanne's personal life made headlines around the world when she announced that she was an incest survivor. Now, she says she wishes she'd gone about it a different way.
"I think it's the worst thing I've ever done," she says. "It's the biggest mistake that I've ever made."
"Calling it incest? Or going public?" Oprah asks.
"Well, both of those things," Roseanne says.
Roseanne says she was in a bad place in her life when she made the accusations about her parents. "I think what happened was that—well, I know what happened was that I was in a very unhappy relationship," she says. "I was prescribed numerous psychiatric drugs. Incredible mixtures of psychiatric drugs to deal with the fact that I had, and still in some ways, have and always will have some mental illness. And the drugs and the combination of drugs that I was given, which were some strong, strong drugs, I totally lost touch with reality in a big, big way."