On Grey's Anatomy, Patrick plays a debonair doctor who's deciding between two women, but in real life, he's a happily married father of 4-year-old Tallulah.
Patrick recently learned that his wife Jill is pregnant...with twins! "McDreamies or McDreamettes?" Oprah asks.
"McDreamies," Patrick says. "I think it's going to be a lot of fun. You just want a safe pregnancy and birth, and [you want] the boys to be healthy...and patience when they're crying."