Charlize Theron and Oprah

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For thousands of teenagers in KwaZulu-Natal, South Africa, HIV education and treatment is unavailable or too expensive. The community is severely affected by HIV, with adolescents having a one in two chance of being infected with HIV during their lifetime if nothing changes.

With the help of Charlize and Oprah's Angel Network, a program called Mpilonhle—meaning, "a good life"—has been created to bring free HIV education and treatment directly to schools. The program provides a mobile health unit that travels between four remote high schools. Each month, the mobile clinic brings lifesaving tests and treatments to thousands of students.

"Medical staff told me many students here have lost one or both parents to AIDS," Charlize says. "The mobile clinic is one of the few places offering help, guidance and a safe place to talk."