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The Needle Pain Factor
Without any anesthetic, injections (whether a filler or Botox) can feel like anything from a mosquito bite to a bee sting. Most doctors will apply a topical numbing cream beforehand; collagen fillers are always premixed with an anesthetic to further minimize discomfort. Many doctors will also administer a "nerve block" (a shot similar to the one you get at the dentist) to numb the entire area so you'll hardly even feel a prick. This is almost always done when you're getting a filler in the lips or near the mouth, by far the most sensitive area of the face.