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Although almost every human being in history has been lonely, most of us aren't so great at helping someone else through it. Robert Weiss, PhD, the godfather of research in the field, thinks that's because once loneliness abates, amnesia sets in. Having forgotten the intensity of their own experience, many people cavalierly offer advice that would have sent them over the edge—"Be more outgoing!" or "Chin up!"—to others still struggling. Here are a few reminders...

A Small Gesture
A lonely person's pity meter is a finely tuned instrument. There is no greater kindness than not extending an overly magnanimous invitation that makes her feel like the neighborhood charity case. A small gesture—an offhand invitation to lunch—is often a better antidote.

Dinner and A Movie
Some people are so debilitated by loneliness that they can hardly discuss it (or anything else). Inviting a friend to a concert or movie will give you something to talk about over dinner.

Prescription for Success
Offer to accompany her to a medical appointment. One study found that doctors said they treat socially isolated people less well than patients with supportive families, and they've seen other health practitioners do the same.

Try Not to Cancel
Try not to reschedule plans or cancel at the last minute. Lonely people tend to see social engagements as life buoys in a long week; canceling can leave them feeling unmoored.

Checking In
Leave a message. A voicemail or e-mail can make her feel she hasn't been forgotten.

Reality Check
Since research shows that the lonely tend to remember more details about their social encounters and often interpret remarks and nonverbal messages negatively, you might give her a different interpretation of her officemates' behavior or be her reality check at a party.