Oprah sits down with Reese Witherspoon and Mindy Kaling, her co-stars from the film "A Wrinkle in Time," for a lively conversation about ambition, guardian angels, learning to say no, and the pressures women face in today's culture. Reese and Mindy discuss the hardest decisions they had to make in order to fulfill their destinies. Oprah says, "I'm so excited to have a conversation with such beautiful, innovative, powerful women." Directed by pioneer filmmaker Ava DuVernay, "A Wrinkle in Time" is adapted from Madeleine L'Engle's classic 1962 novel of the same name. The movie is about a young girl, Meg Murry, played by newcomer Storm Reid, who hops through time to rescue her father from an evil, universe-threatening force. Ava describes the story as a tapestry of "spirituality and self-empowerment." Disney's "A Wrinkle in Time" has its premiere in movie theaters on March 9, 2018.