Julia Roberts on having twins.

She's won an Oscar®, found her dream man in husband Danny Moder, and will soon give birth to twins! Julia is having the time of her life and is so excited for not one, but two babies—a boy and a girl!

"I feel like it's classic overachieving," Julia jokes. "I see some lovely woman walking on the street pregnant with one child and I think, 'What's the point? Go for two!' … [When I told my mom,] the knower of all things but the teller of few, I said, 'You know, I have great news, I'm going to have a baby. Well, actually, we're going to have two babies.' My mom says, 'Of course you are. We have twins in our family.' I'm 36! She tells me now?"
Julia Roberts on pregnancy

Oprah: Are you having any kind of hormonal mood swing kind of thing? Or should I ask Danny this question?

Julia: No, you know what it is, I have this terrifying laugh now and…

Oprah: I thought you've always had it!

Julia: No. It's so much more horrifying now. I think Danny thinks a trucker has swallowed his wife!
Debra Messing advices mom-to-be Julia Roberts

There's a big baby boom in Hollywood, and one of the new moms, Will & Grace star Debra Messing, wanted to give Julia a heads up on what to expect by sharing one of her fondest "new mommy" memories.

"I lifted up my son with love and delight after feeding him, and he proceeded to vomit into my mouth," Debra says. "I thought it was hilarious. I love him so much that I would like to put his drool in a bottle and wear it as perfume. I hope that your two gifts fill you with as much love, light and joy as my baby brought me. And I can't wait to meet them. Let's have a play date!"
Ray Romano gives advice to Julia Roberts

Ray Romano's not only TV's funniest dad, he's also the proud father of 11-year-old twin boys. He sent a personal message to Julia, giving her a taste of things to come.

"Julia, here's my advice," Ray says. "From now until they're born, I want you to just sleep and have sex, because those things are going away! … You're in for a fun time. I would say, Julia, to you, God bless. But He already has."
Julia Roberts

The movie Closer is the ultimate tangled web of love that lures you in with chilling tales of cheating. Dan, played by Jude Law, is a struggling writer who meets lonely Alice—Natalie Portman—in a chance encounter. But he also falls hard for confident Anna, played by Julia Roberts. Anna is married to Larry—Clive Owen—who later hooks up with Alice.

Julia credits director Mike Nichols with the movie's "brilliance" and "great architecture."

"Everything he says is like a pearl," Julia says of Nichols. "He said this movie is all beginnings and endings. There's no middle. Middle is boring. Everybody sits around doing middle all day long. This is just the beginning and the end, which are the most intense moments of our lives, of our relationships, of our everything. And I think the rest of the cast had already clued into that, and I just thought it was the most fascinating piece of information I ever received in my life. I was, like, 'There's no middles?' There are no middles. It's all, 'Nice to meet you. I love you. Guess what, I don't love you anymore.'"
Natalie Portman

Closer showcases a riveting performance by the extraordinary Natalie Portman. Discovered at just 11 years old, her career took off on the stage and big screen, acting alongside Hollywood royalty such as Jack Nicholson, Glenn Close and Al Pacino. Six years later, she shot to superstardom playing Queen Amidala in Star Wars. Natalie has turned heads on the red carpet with her elegant, simple style that's often compared to Audrey Hepburn.

In Closer, Natalie shows off a very sexy side! To prepare for her role, Natalie visited strip clubs and talked with dancers—and took pole dancing lessons!

Oprah: Did you think it was brave of you taking the part? When you read it, and you said what?

Natalie: I just, I get excited by something that's challenging and different, and that I haven't done.
Clive Owen

Clive Owen drove his way into the Hollywood spotlight in edgy BMW ads. Since then, this tall, dark, green-eyed Brit has built an impressive resume. Clive faced off with Matt Damon in The Bourne Identity, went Beyond Borders with Angelina Jolie and ruled the big screen as King Arthur. In Closer, Clive plays Julia Roberts' scorned husband who won't go down without a fight. In real life, Clive met his wife while they were playing Romeo and Juliet on stage! They now have two daughters.

Oprah: What a great job you did. You did an excellent job. And you're so convincing. What was it like playing [Julia's character's] husband?

Clive: It was fantastic. The whole experience of this film, for me, was like a gift.

Oprah: Is it true that you had said to somebody you were amazed at Julia's talent?

Clive: Well, yeah. Of course. I always think that…the very special ones are the ones that make it look so easy, and it's really easy to take that for granted, you know. To be that good and that confident in front of a camera, and working with the lady here is just—she's impressive when you see her. It's, wow, that's why Julia Roberts is the biggest actress in the world.