Sadie and Oprah

Photo: George Burns/Harpo Studios

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Oprah has always been a major advocate of pet adoption, so in 2009 she went to PAWS Chicago, a no-kill animal shelter, where she fell madly in love with Sadie.

As a puppy, this cocker spaniel overcame parvovirus, but today she is known as the mascot of Harpo and is not afraid to speak up during Oprah's meetings.