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In her latest movie, Rabbit Hole, Nicole plays a grief-stricken mother who's dealing with the death of her young son. Critics are calling Nicole's performance the best of her career.

Watch an exclusive clip from the movie Rabbit Hole. Watch

After Oprah saw the film, she says she almost called Nicole—like Oprah did after seeing The Hours—to tell her she'll win another Oscar®. Nicole remembers the call. "[Oprah] said, 'Nicole, you're going to win the Oscar.' I was like, 'Oh my God...Oprah knows!'" Nicole says.

Despite the dark subject matter, Nicole says the story is more about love and family than death. "It's about a mother's love and a father's love," she says. "As much as it looks incredibly emotional, I feel like there's hope there. It's reaching out, and it's saying you can go through these things and still have your marriage."

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