The laughing quadruplets

2 of 11
To celebrate the end of its 18th season, AFV producers have given The Oprah Show unprecedented access to some of their all-time favorite videos.

One of the most popular clips stars quadruplets who are spending some quality time with Mom. Whenever their dad does something funny from behind the camera, the foursome erupts in an orchestra of laughter.

"It's just something about it that's so sweet and natural," Oprah says.