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After a week in our nation's capital to cover President Barack Obama's historic inauguration, Oprah is back in Chicago where more hot topics are coming to the forefront.

During The Great Debate: Should You Replace Your Hormones? Oprah started a conversation she feels very strongly about. Women around the world who felt tired, flat, lifeless and imbalanced wrote in saying they felt the same way.

Wendy says she has been taking bioidentical hormones for 13 months, and it has changed her life. "My doctor and I tease about having a new birth date because the day that I started the hormone treatment was one of the best decisions I've made—I think probably the best decision I've made in my life," she says. Wendy says her migraine headaches, depression and low energy disappeared once her doctor helped her find hormonal balance.

Do you have questions about hormonal replacement therapy? Join us on Thursday, January 29, at 9/8c for an exclusive Oprah.com webcast. Register now to save your seat!