Photo: Atsushi Nishijima © 2017 Disney Enterprises Inc. All rights reserved.

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"I loved playing the wisest character," says Oprah (here with DuVernay), who drew upon her news-anchoring days to give Mrs. Which her deep, commanding voice. "Wise people never have to raise their voices. There was a scene where Chris Pine, who plays Dr. Murry, wanted me to become agitated, and I told Ava, 'Mrs. Which doesn't get agitated.' When you've been around for millennia, there's no need!"