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They were proud; they were prejudiced. It wasn't love at first sight, but after sufficient banter and bickering, they started a romance that was one for the books.

Photo: Courtesy of Everett Collection

In the real world, stuffed bears and pigs rarely become best friends. In the Hundred Acre Wood, this interspecies pair walks forever paw-in-hoof.

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A history-changing wartime alliance and mutual admiration society fueled by liquor, cigars and a shared commitment to the salvation of humankind.

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She may have been made of hard maple and steel strings, but to King she was partner, muse and everything in between.

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Ain't nothing like the real thing: The duo made seven Top 40 hits together, and after Terrell died in 1970, Gaye changed his sound forever.

Photo: LucasFilm LTD. & TM

Two rogue smugglers—one with significant body-hair issues, the other with significant hair—battle the Empire in a galaxy far, far away.

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Oprah + Gayle, 40 years and counting
Gayle: Knows the lyrics to every pop song ever written; makes butterflies look antisocial. Oprah: "Please stop singing, Gayle, and let me read my book." And yet, the epic BFFs can't go a day without talking, laughing and utterly mind-melding.