Toward the end of Randy's full life, Dr. Oz says he spoke with him about hope. "I always thought hope was making sure things would turn out right, and of course, he knew they wouldn't," Dr. Oz says. "He said, 'In my family, hope is just making sense of things.'"

Dr. Oz says he asked Randy what his biggest regret was, and the eternal overachiever answered, "I couldn't find a cure for cancer."

Jai says her husband always made every moment count. "He didn't have a bucket list," she says. "He did everything that he wanted to do in life."

More of Dr. Oz's most memorable moments