Dr. Sheldon Rubin is veterinarian to Oprah's two pups. According to Dr. Rubin, two or three animals is the maximum number of pets to have in a small home in order to take care of them properly.

"When you take that many cats and put them into that small of a square-footage area, there are going to be problems," Dr. Rubin says. "They are really very territorial and they have this zone around them that's very, very important to make a good social environment."

Dr. Rubin says it would be much better to leave that animal as a homeless animal outside than putting it into a stressful environment where it will not get the attention it needs.

"One person can't take care of 81 cats and give that kind of [individual] time," Dr. Rubin says. "That cat will always be shy and will live under a piece of furniture or under somebody's bed for [its] entire life."