Watch Demi Moore and Ashton Kutcher video in which they challenged friends and colleagues to state their pledges on record. More...

A tribute to some of the mothers and fathers who lost their lives in the attacks on September 11, 2001. More...

It's one of Oprah's favorite stories ever. Get the stunning update! Plus, the little family with who's living large and history-making sextuplets. More...

Meet the grandma with the world's smallest waist. Plus, the world's fastest clapper and Swee' Pea, the jump-roping dog! Then, Ken Follett, author of The Pillars of the Earth, is here! More...

American Idol's Simon Cowell reveals his hottest discoveries! From secretary to superstar, Leona Lewis makes her American debut. Plus, the third Big Give contestant sent home is here! More...

They may look like ordinary kids...but what they're getting ready to do on our stage will blow you away! Meet a 15-year-old who's bringing down the house. More...

Dr. Oz and Dr. Prudence Hall discuss bioidentical hormone replacement therapy. More...

Esmee Denters describes what it's like to go from waitressing in a pancake house to singing on the Oprah stage as one of YouTube's biggest stars. More...

Watch Oprah explain how you can make a difference in the life of less fortunate women and children around the world. More...

On a mission for the United Nations' World Food Program, Hollywood star Drew Barrymore helped thousands of children in Kenya. They wanted just two thingsone meal a day and the chance to learn. More...

One guest says she was so fearful, she moved to a different country. And, a prince's secret was so taboo, it ripped his royal family apart. A look at what it is like to be gay around the world. More...

Forty years after conquering his fear of flying, Sean D. Tucker is living his dream as an extreme pilot! More...

Matthew Broderick stars as Ben Singer in the movie Wonderful World. More...

Eco-adventurer David de Rothschild takes a break from sailing the Pacific on the Plastiki to check in from Christmas Island. More...

A most unusual skin treatment, the drink women swear by and the nose-job capital of the world. Plus, the place where men think bug butts and stretch marks are gorgeous! More...

One guest says she was so fearful, she moved to a different country. And, a prince's secret was so taboo, it ripped his royal family apart. A look at what it is like to be gay around the world. More...

American Idol's Simon Cowell reveals his hottest discoveries! From secretary to superstar, Leona Lewis makes her American debut. Plus, the third Big Give contestant sent home is here! More...

A tribute to some of the mothers and fathers who lost their lives in the attacks on September 11, 2001. More...

The story begins with Elizabeth Gilbert praying on her bathroom floor and ends with a spectacular and soul-searching journey around the world. More...

Why Oprah says we are all more alike than we are different. More...