But it also happens to be the mistake of choice for modern science. It will help the mind side of the debate to read the recent cover story in Newsweek, which proclaimed, in stark terms, "Antidepressants don't work."
The support for this bold and disturbing claim comes from previous articles in scientific journals, where the whole rationale for giving a pill to treat depression was undermined. First, when a patient comes to the doctor complaining of mild to moderate depression (the kind most commonly encountered, as opposed to the crippling disorder known as severe chronic depression), for up to 50 percent of people, the standard antidepressants offer no improvement. Some studies indicate that the placebo effect is just as reliable and offers just as much relief as these medications.
Yet for the mind-brain debate, it's another research finding that stands out. The brains of depressed people aren't different from the brains of undepressed people. It has long been assumed that depressed brains are deficient in two vital neurotransmitters called serotonin and dopamine. Taking an antidepressant was supposed to rectify this imbalance. But studies indicate that the genes responsible for the secretion and regulation of neurotransmitters are the same in depressed people as they are in undepressed people.
Which means that your brain may be used to being depressed. It may even be used to a chemical imbalance of some sort. But to focus solely on the brain is to miss major causes of depression that are mental instead. Think of the experiences that can make a person depressed, meaning someone with a mind:
- Outside stress
- Personal crisis
- Physical illness
- Sudden life changes
- Accidents and unforeseen setbacks
- Loss of job or money
- Personal insecurity
- Bad parenting
- Low self-esteem
- Negative religious beliefs leading to guilt and shame
- Other causes of guilt and shame
- Rejection in love
- Being around other depressed people, particularly family members
- The X factor
Are antidepressants helpful?