Is Testosterone Replacement Safe?

There is very little data about the safety and long-term effects of testosterone supplementation in women. Testosterone is converted in the body to estrogen, and it is thus possible that testosterone could compound the carcinogenic effects of estrogen on the breast and the uterus. Side effects of testosterone supplementation can include rages or anger, voice deepening, acne, facial hair, weight gain and liver disease. Many members of the medical community have not embraced testosterone therapy for women. They believe that without long-term studies to support its efficacy and safety, testosterone should be used cautiously, if at all.