Actress Cameron Diaz is probably best known for her performance in romantic comedies like There's Something About Mary, Shrek and My Best Friend's Wedding. This summer, she's taking on a new kind of role, playing the mother of a cancer-stricken young girl in My Sister's Keeper. Cameron's character has dedicated her life to saving her daughter, but when she and her husband have a second daughter for "spare parts," the family faces even more emotional battles. 

Watch a trailer. 

Ali Wentworth, Mark Consuelos and Gayle King, who saw a screening of the movie, say they still can't stop thinking about it. "It's agonizing," Gayle says. "You understand all points of view. It's so well done and so well cast."

• My Sister's Keeper opens in theaters on June 26
• Kelly Ripa visits with the Fridays Live panel

From The Oprah Winfrey Show Oprah Fridays Live with Cameron Diaz