CHICAGO — After five years and 55 episodes, Dr. Mehmet Oz, better known as Dr. Oz, wraps up his time as an Oprah Show regular with an unforgettable hour on The Oprah Winfrey Show Tuesday, May 12. This special Best of Dr. Oz farewell episode marks his last Oprah Show appearance before launching The Dr. Oz Show in syndication on Monday, September 14.

Moving personal stories and extraordinary surprises are featured throughout the hour as Dr. Oz meets viewers who share how his advice saved their lives. From those who noticed life-threatening diseases their doctors missed to those who lost weight thanks to diet tips from Dr. Oz , real people step forward to offer their thanks to "America's Doctor." Plus, it's the reunion that Dr. Oz never imagined would happen, as Oprah Show producers track down a young boy he cared for in the aftermath of Hurricane Katrina and the two reunite for the first time .

Memorable show guests are also featured, from those whose embarrassing questions sparked a national conversation to those whose journeys touched viewers' hearts. Jai Pausch, widow of Randy Pausch, professor and author of the best-selling The Last Lecture , remembers his visit to The Oprah Show and speaks about his legacy today.

Finally, Oprah and Dr. Oz reminisce about some of their funniest moments and raise a glass to each other in one final moment together on the Oprah Show stage.

The Oprah Winfrey Show: The Best of Dr. Oz airs Tuesday, May 12, 2009 (check local listings).

The Oprah Winfrey Show has remained the number one talk show for 22 consecutive seasons, winning every sweep since its debut in 1986.** It is produced in Chicago by Harpo Productions, Inc. and syndicated to 214 domestic stations by CBS Television Distribution Group and to 145 countries by CBS Paramount International Television.

**Nielsen Cassandra Ranking Report - Nov'86 to July '99 and Wrap Sweeps, Nov '99 to July '08. Primary Telecasts Only.