For the first time in 25 years, Oprah welcomes a sitting president and first lady to her stage. Inside her historic interview with the Obamas.
In 25 seasons, The Oprah Show has taken on some of the biggest stories of our time. Look back at 17 of the most memorable.
What the former commander-in-chief says about his difficult decisions surrounding September 11 and Hurricane Katrina
One of the world's most famous interviewers turns the spotlight on herself. The legendary newswoman opens up.
The former vice presidential candidate and Alaskan governor on family, her future and what went wrong during the election.
Nearly 61 years after leaving Auschwitz, Elie Wiesel returns to the site of the death camp with Oprah.
The Duchess of York reveals what really happened during her headline-making bribery scandal.
The former LAPD detective shares shocking revelations about the key players, evidence and what went wrong during the O.J. Simpson trial.