A report on the marriage of Heather and Ron Samuels, who, even after divorcing, were involved in a bitter custody battle.

"The Boston Strangler" - a report on a new investigation of a 1964 murder case, evaluating new evidence that suggests that Albert DeSalvo, thought to be the Boston Strangler, may not have been the infamous killer.

In September, 2006, Nina Reiser disappeared from Oakland, California. Authorities are convinced she is murdered. Suspects include her estranged husband, and a jilted lover with a violent past.

Oprah met Kris and Daisy in 2007, a young brother and sister whose mother abandoned them seven years ago. Producers found the mother in a Texas county jail. Oprah travels to the jail, where a dramatic, painful and emotional reunion takes place.

Oprah speaks with cyclist Lance Armstrong in his first interview since he was stripped of his Tour de France titles. He addresses the alleged doping scandal, years of accusations of cheating and use of performance-enhancing drugs throughout his career.