They were the most loving couple, their friends said. You could see it in the young husband's devotion, nursing his wife during a mysterious illness, as she grew more debilitated and depressed by the day.

A small child is the only witness to a terrible crime: the murder of her mother. But investigators say they can't rely on her testimony, because she is just a toddler.

Mike Sisco and his fiancee, Karen Harkness, were shot to death in Karen's Topeka, Kansas home. The police investigation turned to Dana Chandler, Mike's ex-wife and the mother of his two children who had harassed and stalked the couple.

Oprah:Where Are They Now? updates us on what happened to some of the biggest headline makers of the '90s: Rodney King, Kato Kaelin, and Shannon Faulkner. The episode includes never-seen-before footage of Rodney King's last interview before he passed away

Oprah: Where Are They Now? unlocks the The Oprah Winfrey Show vault and takes a look back at '90s newsmaker Mary Jo Buttafuoco and the 28-year old addicted to plastic surgery. Tune-in for updates from these guests and more!

Oprah: Where Are They Now? looks back at one of the highest rated Oprah shows, "The Alaskan Men Looking for Brides" Plus, the cheating husband who couldn't promise he'd stay faithful. And, the sexy mom who got a drastic make-under.