Oprah visits the larger than life Bette Midler at her home in NYC to talk about her legendary career and latest movie with Billy Crystal. Valerie Simpson of Ashford & Simpson talks to Oprah about the loss of her husband of 37 years, Nick Ashford.

Oprah sits down with award-winning actress-singer Jennifer Hudson for an intimate conversation at her home in Chicago. Her fiancé, David, talks about their relationship and her sister, Julia, speak on the family tragedy and its impact 4 years later.

Can these old flames be reignited?

This story involves a young mother who disappeared one morning. Her husband said she went for a run.. and never came home. It was a puzzling case. It happened in a safe, suburban neighborhood.. the kind of place where crime is unexpected.

They were the most loving couple, their friends said. You could see it in the young husband's devotion, nursing his wife during a mysterious illness, as she grew more debilitated and depressed by the day.

A small child is the only witness to a terrible crime: the murder of her mother. But investigators say they can't rely on her testimony, because she is just a toddler.