Oprah and Debra look back at Oprah's most unforgettable guests; The Sound of Music cast reunion, Mattie Stepanek, and an emotional reunion with Oprah's favorite childhood teacher.

Oprah and Debra look back at the show's most captivating moments, including interviews with author James Frey and members of the Little Rock Nine.

Oprah sits down with TV legend Kelsey Grammer. He sets the record straight about his public divorce, drug addiction, his new show, Boss; and the tragedies that shaped his life. His new wife, Kayte, does her first television interview.

In September, 2006, Nina Reiser disappeared from Oakland, California. Authorities are convinced she is murdered. Suspects include her estranged husband, and a jilted lover with a violent past.

You're about to meet some women, a bit out of the ordinary. There are moms, a grandmother, a business maven and a newlywed. One's high society, another's a member of law enforcement. What's extraordinary about them is that each is about to order a hit...

The story of a double murder that was both shocking.. and puzzling. There were no witnesses and few clues.