Is it hard to be a young girl with big dreams in Haiti? Watch as the Lighthouse Orphanage founders Bill, Sue and Ariana Manassero open up about the challenges facing girls in Haiti and their dreams for every child that passes through their children's home.

Oprah speaks with an American couple who run a home for children in Haiti and were in the country when the earthquake struck in 2010.

Bill and Sue Manassero share with Oprah how they came to Haiti with their daughter, Ariana, to care for orphaned Haitian children.

Oprah tours a Haitian work space with Magalie, a local Haitian entrepreneur, who is rebuilding her country by giving local women jobs making art.

While in Haiti, Oprah talks with fashion designer Donna Karan about her late husband, Stephan Weiss, and how she remains connected with him.

Sean Penn had a great childhood. Today, he has a life many people would envy. Still, he says he wrestles with a lot of angst. Watch Sean reveal what is behind his hostility.

Actor and humanitarian Sean Penn's divorce to actress Robin Wright was finalized in 2010. In this sneak peek, watch as he tells Oprah how being single has changed him in this sneak peek.

For many earthquake survivors, life at the J/P HRO camp has meant adjusting to a new normal. Meet Touissant, a father of two who lost his wife in the earthquake, and find out what life is like for his family today.

Six days after the 2010 Haiti earthquake, Sean Penn hopped on a plane for what he thought was a two-week relief mission. Two years later, he's still there. Watch as he gives Oprah an inside tour of the tent relief camp run by his organization, J/P HRO, and explains how they are helping the 20,000 Haitians who currently live there build independence.

In 2010, Sean Penn and Robin Wright divorced after 14 years of marriage. Watch as Sean explains how his work in Haiti helped him through the divorce and discusses what his relationship is like with Robin today.