One of the biggest mysteries on the block is why Mary Alice killed herself. Brenda Strong is the actress who brings Mary Alice to life by narrating the trials and tribulations of the women of Wisteria Lane each week. But would she reveal to Oprah the show's biggest secret?
Oprah: Do you know why you killed yourself?
Mary Alice: I can't tell you.
Oprah: Now that you're dead, do you think it was worth it, killing yourself over it?
Mary Alice: Now that I know we have a hit show? Absolutely not!