Over the last 25 years, The Oprah Show has devoted hundreds of episodes to the topic of weight loss. Like millions of women, Oprah has struggled with her weight—a struggle that has been quite public ever since the show started in 1986. "I've been ripped to shreds eight ways from Sunday for my weight," Oprah says. "But no one has been harder on me for my weight than I have. And I know many of you can relate to that."
Look back at Oprah's weight loss journey
For the last weight loss show in Oprah Show history, the audience was filled with 100 loyal viewers who have been on their own personal weight loss journeys—and each one of them lost at least 100 pounds in the process!
Meet Sandra who lost 106 pounds