6. Julia Roberts
With her megawatt smile and infectious laugh, it's no wonder why award-winning actress Julia Roberts has been on the Oprah Show
21 times. Since Julia's first appearance in 1989, she's become a wife, a mother of three and a dear friend of Oprah's.
Oprah and Julia have made a lot of great memories over the years, like Julia's best friend's makeover and Julia's first interview with Tom Hanks
Fun fact: Did you know Oprah and Julia were in a movie together? Find out which one!