The Anatomy of 'Grey's'

Oprah's first stop at Seattle Grace is the infamous elevator where some of Grey's Anatomy's most intense scenes have taken place. The actors most responsible for steaming up the elevator are Ellen Pompeo and Patrick Dempsey.

In the show's premiere episode, Ellen's character, Meredith Grey, has a one-night stand with a man she meets in a bar...only to find out the next day that he's a top surgeon at the hospital where she's an intern. Patrick plays Dr. Derek Shepherd, a neurosurgeon who Meredith and her friends affectionately nicknamed "Dr. McDreamy."

After a brief romance, Meredith finds out that McDreamy is still married to his estranged wife, who's joining the Seattle Grace staff. Millions tuned in every week to see how this love triangle would play out. Finally, after months of waiting, Oprah and other Grey's fans were thrilled to learn that Meredith and Derek may finally make it work!

"I think it's nice we've gone through that phase of the relationship and we're now going forward, and we can see how they work out their conflicts," Patrick says.

Ellen says she's also excited that her character's true love finally came around. "It's fun to not be fighting anymore," Ellen says.