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She's been Knocked Up , has worn 27 Dresses and won an Emmy for her stand-out role as Izzie Stevens on Grey's Anatomy —it's no wonder Katherine Hiegl is being called Hollywood's "it" girl. Watch Katherine get serenaded by good friend and former co-star T.R. Knight. In the song, T.R. sings, "It's all about how you're the awesomest of dames. And you're a great friend, a friend to the end. You're there without fail. We're like Oprah and Gayle!"

Learn about Katherine's Hollywood love story and hear from Grey's Anatomy creator Shonda Rhimes.
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