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Dave welcomes Oprah to New York City.
Start spreading the news! For her 22nd season premiere, Oprah took her show on the road to the only place big enough to hold it…Madison Square Garden in New York City!

For her first guest of the season, Oprah called on the man who rules New York's late nights for a special daytime appearance. He rarely does interviews, and she's never interviewed him before—host of the Late Show, David Letterman.