Heroes and Stars of Ladder 49

As luck would have it, Oprah and John turned 50 within weeks of each other.

John originally thought he would spend his big birthday quietly. Little did he know, wife Kelly Preston had cooked up a star-studded, mega-fiesta weekend in Las Cabos, Mexico to honor her husband! The 250-person "A list" included such stars as Barbra Streisand, Sylvester Stallone, Meg Ryan, Robin Williams, Tom Cruise, Carly Simon and Oprah. Oprah says it was a first for her—she drank tequila until dawn!

John says he had a revelation about turning the big 5-0, "You feel alive to the degree that you feel you can help others."