To start the festivities, Oprah dances onto the stage with one of her all-time favorite guests, John Travolta. "There is really no one on earth I'd rather be with in this moment than you," she says. "Twenty-five years later, you still make my heart go pitter-patter."
John has appeared on The Oprah Show 11 times and says that being on Oprah's stage feels like coming home. "If I may be so bold as to speak for the public, speak for the world, you have this rare ability to inject knowledge, help, hope, love and art into the culture," he says. "Oprah, there's only one of you, and there will never be another one. You are our queen, and we thank you for allowing us to be part of your life. And we're lucky to be a part of your life."
Look back at some of our favorite moments with John
Oprah is also joined by an audience of 300 of her biggest fans. "You are all so loyal, we call you the 'ultimate,'" she says. "You have all been on this wild ride with me every step of the way, and for that I have deep, heartfelt gratitude to you all. To those of you in this audience and those of you in the audience at home."