What are two questions everyone wants to ask John? First, will he ever join the family business run for office?
"I certainly thought about it. I really grew up in a political environment," he says. "And it was important to do something different. John Adams said that you should become a politician at the end of your life when you bring a wealth of life experience to bear on that office. I was eager to try something different, to see another part of life."
Second, when is he getting married? But Oprah says she purposely did not ask this one. "Because it's the number one question everybody asks me!" she says. "And I don't think it's anybody's business but his."
Find out what Oprah was really thinking during this historic interview