Comedian George Lopez analyzes the current state of late night, why he thinks it's taken so long for a Hispanic host to helm a late night show and why he can't wait to get started.

In an open letter to the People of the Earth, Conan O'Brien announced he would not host The Tonight Show in the 12:05 time slot after Jay Leno.

A truly stand-up guy of late-night television talks about his life growing up, his work life and his married life (with the Nobel Peace Prize-nominated Mavis Leno).

Despite what's been passed down in late-night war lore, talk show host David Letterman tells Oprah his rivalry with Tonight Show host Jay Leno did not start when Dave was passed over for Johnny Carson's old seat. Watch as he reflects on his old friend and reveals why Jay is the funniest guy he's ever known.

Oprah sits down with legendary late-night talk show host David Letterman. In this rare interview, David discusses his rival, Jay Leno; his public sex scandal; and how he repaired his marriage. Plus, David opens up about his battle with depression.