Eighteen months after his 2006 appearance on The Oprah Show, James faced a devastating personal tragedy. His son, Leo, was born with an incurable and fatal neuromuscular disease called spinal muscular atrophy. Leo died 11 days later.
Watch James talk about Leo's passing
To this day, James says he has not recovered from losing his first son. "I think there are a lot of things in my life I've recovered from, [but] I don't know if I'll ever recover from that," he says. "That's a wound that's open."