Best friends Oprah and Gayle look back on 25 years of special moments shared on The Oprah Show.

New series include Oprah's Next Chapter, Visionaries: Inside the Creative Mind, Your OWN Show: Oprah's Search for the Next TV Star, Gayle King Live! and Why Not? with Shania Twain. Jay-Z, Bono, Simon Cowell, Lorne Michaels, Toni Morrison and Condoleezza R

Oprah and Gayle King sit down to talk about what, for Oprah, is the biggest change in 25 years: the end of The Oprah Winfrey Show.

Take a look back at Greg Louganis' 1995 appearance on The Oprah Winfrey Show, when the Olympic icon came out with his homosexuality and HIV-positive status.

Interventionist Brad Lamm talks about a gay student whose photo was emitted from her high school yearbook. Plus, he shares his thoughts on why being gay isn't always easy.