Oprah meets Mattie Stepanek, an 11-year-old poet with muscular dystrophy, who is one of the most inspiring guest in Oprah Show history.

How a young guest helped her prepare for the next chapter and move forward with no regrets - only grace and gratitude.

In 2002, Kathrine Lee strutted her 175-pound weight loss across Oprah's stage. By 2009, she had gained 150 pounds back. How she lost another 100 pounds by simply learning to love herself.

Over the years, Oprah has been very open about her struggles with weight. But after all these years, she says she's finally found the answer.

Oprah Radio' host Dr. Maya Angelou talks to Mattie Stepanek's mom, Jeni.