Charlotte's Web

It's a first for Oprah—she's making her first feature film with one of the biggest movie stars on the planet, Julia Roberts! "She and I are friends, and that's what our new movie is all about," Oprah says. "It's about friendship."

That movie, of course, is Charlotte's Web. The film adaptation of the beloved children's book by E.B. White hits theaters December 15, 2006. In the film, Oprah lends her voice in a supporting role as Gussy, a goose. Julia voices the film's main character, Charlotte the spider. She took the role on only six weeks after having her twins!