The cameras are ready to go as final preparations are made before the taping of a show featuring performances by Justin Timberlake, Reba McEntire and Kelly Clarkson.
Middlesex is the astonishing tale of a gene that passes down through three generations of a Greek-American family and flowers in the body of Calliope Stephanides.
The first graduates of the Oprah Winfrey Leadership Academy for Girls take flight.
Watch videos with Oprah Book Club authors, including Ken Follett, Cormac McCarthy, Toni Morrison, Sidney Poiter and Jeffrey Eugenides.
Jeffrey Eugenides tells Oprah about winning the Pulitzer Prize.