Oprah's Big Give contestants weren't the only ones making a difference on this show. Oprah and Simon Cowell head backstage after he paid the mortgage for a family struggling to stay afloat during their 3-year-old daughter's battle with cancer.
Browse Oprah Radio host Dr. Mehmet Oz's past shows.
Browse audio clips from Oprah Radio host Dr. Mehmet Oz's past shows.
Dr. Mehmet Oz and Dr. Michael Roizen biographies
After getting a colonoscopy for his show, Dr. Mehmet Oz finds a colon polyp and a new lease on life. Now, he's teaching the urgency in patient responsibility.