Anything Can Happen

The first guest of our 20th season is the woman everybody wants to talk to: Jennifer Aniston. To congratulate Oprah on her anniversary show, Jennifer brings along a gift—champagne to christen the new set!

After a bit of the bubbly, Oprah and Jennifer get down to business. With her recent divorce displayed throughout the tabloids, Jen has barely gotten a moment's peace. "People were obsessed about your marriage [to Brad Pitt]," Oprah says to Jennifer, "and then your divorce. I think it's because you guys represented the picture on the wedding cake. So [if your relationship] doesn't work out, we think, 'Oh lord, I'm in trouble!'"

Jennifer feels strongly that she will not be defined by her divorce. "It's hard," she says, "when energetically you have all of [the media coverage] coming at you and you've moved on and you just want to say, 'Come on, people, turn a page!'"